that's basically the problem with the law: in some cases, prosecutors have simply declined to press charges, since the only person who could possibly testify to refute the self defense claim is dead.
the law hinges on whether the shooter/defendant reasonably believed their life was in danger.
Here's a portion of the text of the Florida law:
"A person who is not engaged in an unlawful activity and who is attacked in any other place where he or she has a right to be has no duty to retreat and has the right to stand his or her ground and meet force with force, including deadly force if he or she reasonably believes it is necessary to do so to prevent death or great bodily harm to himself or herself or another or to prevent the commission of a forcible felony."
That's it. That's all you need to do in Florida to kill someone and get away with it: convince the jury that you reasonably believed it was necessary to use deadly force to prevent death/great bodily harm.