Just briefly looking this over...
http://www.tankathon.com/nfl
Best case scenario if the Lions win:
Buffalo beats Miami
NY Giants beat Dallas
Jacksonville beats Houston
Atlanta/TB doesn't really matter because a TB win pushes Atlanta in front of Detroit due to SoS and an Atlanta win pushes TB in front of Detroit due to record
I don't think Carolina losing to NO matters because that game will raise Carolina's SoS
Pick 6
Worst case scenario if the Lions win:
Miami beats Buffalo
Dallas beats NY Giants
Houston beats Jacksonville
Atlanta/TB shouldn't matter again
Pick 9
Best case scenario if the Lions lose:
SF beats LA Rams (should raise their SoS enough)
NY Jets beat New England (same as above)
Oakland beats KC
Pick 2
Worst case scenario if the Lions lose:
LA Rams beat SF
New England beats NY Jets
KC beats Oakland
Pick 5
There may be more intricacies to the SoS that complicates things, but just based on week 17 opponent I would say the Lions are going to finish with an SoS below everyone around them besides Atlanta.